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Conclusion: Major depressive disorder is associated with unhealthy astrocytes in the noradrenergic LC, characterized here by a reduction in astrocyte glutamate transporter expression. The authors thank the Quebec Suicide Brain Bank, Mc Gill Group for Suicide Studies, at the Douglas Mental Health Institute for provision of brain tissues.
These findings suggest that increased glutamatergic activity in the LC occurs in men with MDD. The authors also thank the Brain Tissue Donation Program at the University of Pittsburgh for the provision of brain tissues.